In vitro kidney models designed to reflect in vivo renal biology
We are a preclinical CRO focused on renal biology. Using primary kidney cells, we build models that provide data on safety, compound uptake and transport, and cross-species differences, helping you decide which compounds to advance, investigate further or deprioritise.
Renal testing to answer the questions that matter in drug development
We build renal in vitro studies around your compound, your development questions and the decisions your data needs to support.
Better insight into renal safety starts with the right biology
Nephrotoxicity can derail drug development late in the process. FarneBio helps drug developers investigate potential renal liabilities using primary kidney cell models designed to preserve key features of native renal biology.
The challenge of renal safety
Understanding a compound’s potential impact on the kidney requires insight into how it affects renal cells and function. Distinguishing direct cellular injury from effects on kidney function and drug transport is an important challenge in assessing renal safety.
Source: US Food and Drug Administration (FDA), Renal Impairment in New Drug Development
Why primary cells?
Widely used, established cell lines do not fully represent the differentiated characteristics of renal cells, which can influence how they respond to compounds. FarneBio uses freshly isolated, never-passaged primary cells in advanced culture conditions for in vitro studies.
How the cells are sourced
Established tissue supply
Ethically sourced donor kidneys, with multiple donors available for each study
Rapid cell isolation
Within 30 hours of kidney retrieval
Never-passaged cells
Cells are used without passaging before the study
Built on established renal science. Ready for your next programme.
FarneBio builds on established renal in vitro technology with more than seven years of commercial use across 120+ projects for pharma and biotech teams, including top 20 pharmaceutical companies. This track record combines an established technology platform with a team experienced in delivering renal studies to support development decisions.
Our characterised models are available now. We are ready to work with you on current programmes, tailoring studies to the questions that matter for your compounds.
We continue to innovate and aim to launch new models that expand our offering and enable data generation across the discovery pipeline.
Based in Sunderland, North East England, we work with teams across the US, Europe and beyond.
Ways to work with us
Commission studies
Renal in vitro studies designed around your research questions and drug-development needs.
Collaborate
Co-develop new in vitro models, assays and disease models to address emerging research needs.
Partner
Explore strategic, commercial and technology partnerships to extend our reach and capabilities.
Have a question about how our models can support your programme? Let’s talk.
Tell us what you need to understand about your compound, and we will help identify the right renal testing approach.
Thank you
We have received your enquiry and will get back to you as soon as we can.